Lochmolins A-G, new sesquiterpenoids from the soft coral Sinularia lochmodes

Yen-Ju Tseng; Kuo-Ping Shen; Hui-Li Lin; Chiung-Yao Huang; Chang-Feng Dai; Jyh-Horng Sheu

doi:10.3390/md10071572

Lochmolins A-G, new sesquiterpenoids from the soft coral Sinularia lochmodes

Mar Drugs. 2012 Jul;10(7):1572-1581. doi: 10.3390/md10071572. Epub 2012 Jul 20.

Authors

Yen-Ju Tseng¹, Kuo-Ping Shen², Hui-Li Lin³, Chiung-Yao Huang¹, Chang-Feng Dai⁴, Jyh-Horng Sheu^{1

5}

Affiliations

¹ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
² Department of Nursing, Meiho University, Pingtung 912, Taiwan.
³ Department of Food and Nutrition, Meiho University, Pingtung 912, Taiwan.
⁴ Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan.
⁵ Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Abstract

Seven new sesquiterpenoids, lochmolins A-G (1-7), were isolated from a Taiwanese soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1-4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells.

Keywords: Sinularia lochmodes; aromadendrane; germacrane; sesquiterpenes; soft coral.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Cell Line
Cyclooxygenase 2 Inhibitors / pharmacology
Magnetic Resonance Spectroscopy
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology

Substances

Cyclooxygenase 2 Inhibitors
Sesquiterpenes