Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead

ChemMedChem. 2012 Sep;7(9):1541-5. doi: 10.1002/cmdc.201200253. Epub 2012 Jul 30.

Abstract

Lead on! In the course of screening flavonoid and resveratrol libraries, abyssinone II, a naturally occurring prenylated flavonoid, was found to exhibit relatively good antitubercular and antibacterial activity. Preliminary mechanistic studies revealed that abyssinone II hyperpolarizes the bacterial membrane potential and inhibits the biosynthesis of key cellular macromolecules (DNA, RNA, and protein).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Antitubercular Agents / chemistry
  • Antitubercular Agents / pharmacology
  • Bacteria / drug effects*
  • Bacterial Infections / drug therapy
  • Flavonoids / chemistry*
  • Flavonoids / pharmacology*
  • Humans
  • Mycobacterium tuberculosis / drug effects
  • Resveratrol
  • Small Molecule Libraries / chemistry
  • Small Molecule Libraries / pharmacology
  • Stilbenes / chemistry*
  • Stilbenes / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Antitubercular Agents
  • Flavonoids
  • Small Molecule Libraries
  • Stilbenes
  • abyssinone II
  • Resveratrol