The default mode network and related right hemisphere structures may be the key substrates of dementia

J Alzheimers Dis. 2012;32(2):467-78. doi: 10.3233/JAD-2012-120424.

Abstract

We have employed structural equation models to explicitly distinguish dementia-relevant variance in cognitive task performance (i.e., δ) from the variance that is unrelated to a dementing process (i.e., g'). Together g' and d comprise Spearman's "g". Although d represents only a minor fraction of the total variance in cognitive task performance, it is more strongly associated with dementia severity than is g'. In this analysis, we replicate δ in a new dataspace, the University of Kansas Brain Aging Project, and associate it specifically with regional grey matter atrophy by voxel-based morphometry of magnetic resonance imaging data. The latent variable d localizes to elements of the default mode network and related structures in the R hemisphere.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Aging / pathology
  • Atrophy / pathology
  • Brain / pathology*
  • Cognition
  • Cognitive Dysfunction / pathology*
  • Dementia / pathology*
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Models, Neurological
  • Nerve Fibers, Unmyelinated / pathology*
  • Nerve Net / pathology*
  • Neuropsychological Tests