Synthesis of 2-Aryl benzothiazoles via K2S2O8-mediated oxidative condensation of benzothiazoles with aryl aldehydes

Zhiyong Yang; Xiang Chen; Sizhuo Wang; Jidan Liu; Kai Xie; Anwei Wang; Ze Tan

doi:10.1021/jo300740j

Synthesis of 2-Aryl benzothiazoles via K2S2O8-mediated oxidative condensation of benzothiazoles with aryl aldehydes

J Org Chem. 2012 Aug 17;77(16):7086-91. doi: 10.1021/jo300740j. Epub 2012 Aug 2.

Authors

Zhiyong Yang¹, Xiang Chen, Sizhuo Wang, Jidan Liu, Kai Xie, Anwei Wang, Ze Tan

Affiliation

¹ State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.

PMID: 22835066
DOI: 10.1021/jo300740j

Abstract

Nontransition metal-catalyzed synthesis of 2-aryl benzothiazoles was achieved through K(2)S(2)O(8)-mediated oxidative condensation of benzothiazoles with aryl aldehydes. The same transformation can also be effected when the aryl aldehydes were replaced with phenylglyoxylic acids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry*
Benzothiazoles / chemical synthesis*
Catalysis
Glyoxylates / chemistry*
Mandelic Acids / chemistry*
Molecular Structure
Oxidation-Reduction
Potassium Compounds / chemistry
Stereoisomerism
Sulfates / chemistry

Substances

Aldehydes
Benzothiazoles
Glyoxylates
Mandelic Acids
Potassium Compounds
Sulfates
phenylglyoxylic acid
potassium persulfate