Abstract
There is assumption about active role of immune modulators in cell death process. The involvement of interferon-alpha and cycloferon in apoptosis regulation of hypothalamic neurons of mice during stress and aging was studied. We determined the expression of apoptosis markers (Bcl-2, Mcl-1, Bax) in comparison with apoptosis level. We have found that immune modulators suppress activity of nonapeptidergic neurons. Thus, interferon-alpha treatment reduces synthesis of Bcl-2; cycloferon treatment inhibits expression of Bax and Bcl-2. So the role of immune modulators in neuron apoptosis depends on the stage of ontogenesis and type of immune modulator. Cycloferon is able to reduce the level of age-dependent apoptosis of neurons in aging, but under stress condition both interferon-alpha and cycloferon act as protectors of cell death.
MeSH terms
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Acridines / administration & dosage*
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Aging / immunology
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Aging / metabolism*
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Aging / pathology
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Animals
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Apoptosis / drug effects
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Gene Expression Regulation / drug effects
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Hyperoxia / immunology
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Hyperoxia / metabolism*
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Hyperoxia / pathology
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Hypothalamus / drug effects*
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Hypothalamus / metabolism
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Hypothalamus / pathology
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Immobilization
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Immunologic Factors / administration & dosage
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Interferon-alpha / administration & dosage*
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Interferon-alpha / immunology
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Male
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Mice
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Myeloid Cell Leukemia Sequence 1 Protein
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Neurons / drug effects*
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Neurons / metabolism
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Neurons / pathology
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Neuroprotective Agents / administration & dosage
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Neuroprotective Agents / immunology
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Proto-Oncogene Proteins c-bcl-2 / genetics
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Stress, Physiological / immunology
Substances
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Acridines
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Immunologic Factors
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Interferon-alpha
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Mcl1 protein, mouse
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Myeloid Cell Leukemia Sequence 1 Protein
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Neuroprotective Agents
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Proto-Oncogene Proteins c-bcl-2
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10-carboxymethyl-9-acridanone