Abstract
Drawing inspiration from the impressive neurotrophic activity exhibited by the natural product paecilomycine A, we have designed a new natural product-like scaffold employing an intramolecular Pauson-Khand reaction. Several compounds based on the new designer scaffold exhibited promising neurotrophic activity and are worthy of further biological evaluation. Our findings also highlight the importance of a DOS strategy in creating useful therapeutical leads.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biological Products / chemistry*
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Biomimetic Materials / chemical synthesis*
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Biomimetic Materials / chemistry
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Biomimetic Materials / pharmacology*
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Cell Line
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Cell Survival / drug effects
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Nerve Growth Factors / chemical synthesis*
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Nerve Growth Factors / chemistry
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Nerve Growth Factors / pharmacology*
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Stereoisomerism
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Terpenes / chemistry*
Substances
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Biological Products
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Nerve Growth Factors
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Terpenes
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paecilomycine A