Recognizing the translocation signals of individual peptide-oligonucleotide conjugates using an α-hemolysin nanopore

Yi-Lun Ying; Da-Wei Li; Yu Liu; Subrata K Dey; Heinz-Bernhard Kraatz; Yi-Tao Long

doi:10.1039/c2cc32636a

Recognizing the translocation signals of individual peptide-oligonucleotide conjugates using an α-hemolysin nanopore

Chem Commun (Camb). 2012 Sep 11;48(70):8784-6. doi: 10.1039/c2cc32636a. Epub 2012 Jul 26.

Authors

Yi-Lun Ying¹, Da-Wei Li, Yu Liu, Subrata K Dey, Heinz-Bernhard Kraatz, Yi-Tao Long

Affiliation

¹ State Key Laboratory of Bioreactor Engineering & Department of Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China.

PMID: 22832595
DOI: 10.1039/c2cc32636a

Abstract

Two peptide-oligonucleotide conjugates are studied using an α-hemolysin nanopore to investigate their structural properties at the single-molecule level.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Toxins / chemistry
Biological Transport
Circular Dichroism
Hemolysin Proteins / chemistry
Membranes, Artificial
Molecular Conformation
Nanopores
Oligonucleotides / chemistry*
Peptides / chemistry*
Protein Binding

Substances

Bacterial Toxins
Hemolysin Proteins
Membranes, Artificial
Oligonucleotides
Peptides
staphylococcal alpha-toxin