Abstract
A novel 3,4,4a-trihydroxanthene-fused pyrrole 2 was synthesized by the reaction of 2,3,4,4a-tetrahydro-1H-xanthen-1-one with 3-phenyl-2H-azirine in the presence of LDA. Utilizing this pyrrole 2, a NIR BODIPY 1 (λ(abs) = 732 nm, λ(em) = 747 nm) has been prepared. The new BODIPY 1 was stable, non-cytotoxic, and suited to labeling living cells for imaging assay in the NIR region.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Boron Compounds / chemical synthesis
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Boron Compounds / chemistry*
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Boron Compounds / metabolism
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Boron Compounds / toxicity
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Fluorescent Dyes / metabolism
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Fluorescent Dyes / toxicity
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Hep G2 Cells
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Humans
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Infrared Rays*
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Pyrroles / chemistry
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Xanthenes / chemistry*
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Boron Compounds
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Fluorescent Dyes
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Pyrroles
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Xanthenes