[Genetic and environmental contribution to rheumatoid arthritis: a family study]

Recenti Prog Med. 2012 Jul-Aug;103(7-8):279-83. doi: 10.1701/1127.12431.
[Article in Italian]

Abstract

We report on the HLA typing of three brothers (A, B, C) with rheumatoid arthritis (RA) and their six sons. This family is interesting for the full concordance for RA between parents. The aim of this study was the discovery of genetic and/or enviromental cofactors determining this absolute concordance.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / etiology
  • Arthritis, Rheumatoid / genetics*
  • Asbestos
  • Environmental Exposure*
  • Female
  • Genes, MHC Class I
  • Genes, MHC Class II
  • Genetic Predisposition to Disease
  • HLA Antigens / genetics*
  • Humans
  • Male
  • Mixed Connective Tissue Disease / genetics
  • Risk Factors
  • Sex Factors
  • Siblings
  • Sjogren's Syndrome / genetics
  • Tobacco Smoke Pollution

Substances

  • HLA Antigens
  • Tobacco Smoke Pollution
  • Asbestos