The concentrations of 16 perfluorinated compounds (PFCs) were measured in surface water and organisms from Baiyangdian Lake. Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid, and perfluorobutanoic acid (PFBA) were the major PFC species in the water at 6.8-56.8, 0.1-17.5 and 3.0-14.6 ng/L, respectively. The PFC contamination in Baiyangdian Lake was significantly impacted by the inflow from Pinghe River and Fuhe River. There was no significant correlation between the concentrations of PFCs and the trophic levels in aquatic organisms. There were no significant PFC risks in Baiyangdian Lake according to the risk assessment of PFCs in water.