Abstract
Apelin was initially isolated from bovine stomach and is an endogenous neuropeptide. It is a native ligand of the apelin receptor (APJ). Some research has found that apelin peptides alter blood pressure, feeding behavior, and pituitary hormone release. However, a new neuroprotective effect of apelin peptides was only recently discovered. This review summarizes the evidence of apelin-neuroprotection, which has the potential to cure acute and chronic neurological diseases.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apelin
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Apelin Receptors
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Humans
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Intercellular Signaling Peptides and Proteins / pharmacology
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Intercellular Signaling Peptides and Proteins / physiology*
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Intercellular Signaling Peptides and Proteins / therapeutic use
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Nervous System Diseases / drug therapy
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Neuroprotective Agents / pharmacology
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Neuroprotective Agents / therapeutic use*
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Receptors, G-Protein-Coupled / agonists
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Receptors, G-Protein-Coupled / metabolism
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Signal Transduction*
Substances
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APLN protein, human
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APLNR protein, human
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Apelin
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Apelin Receptors
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Intercellular Signaling Peptides and Proteins
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Neuroprotective Agents
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Receptors, G-Protein-Coupled