Bioactive aldehyde-modified phosphatidylethanolamines

Biochimie. 2013 Jan;95(1):74-8. doi: 10.1016/j.biochi.2012.07.010. Epub 2012 Jul 20.

Abstract

Lipid peroxidation generates a variety of lipid aldehydes, which have been recognized to modify protein and DNA, causing inflammation and cancer. However, recent studies demonstrate that phosphatidylethanolamine (PE) is a major target for these aldehydes, forming aldehyde-modified PEs (al-PEs) as a novel family of mediators for inflammation. This review summarizes our current understanding of these al-PEs, including formation, detection, structural characterization, physiological relevance and mechanism of action.

Publication types

  • Review

MeSH terms

  • Aldehydes* / chemistry
  • Aldehydes* / metabolism
  • Endoplasmic Reticulum Stress / physiology
  • Endoplasmic Reticulum* / chemistry
  • Endoplasmic Reticulum* / metabolism
  • Humans
  • Lipid Peroxidation*
  • Molecular Structure
  • Oxidative Stress
  • Phosphatidylethanolamines* / chemistry
  • Phosphatidylethanolamines* / metabolism
  • Reactive Oxygen Species / chemistry
  • Reactive Oxygen Species / metabolism

Substances

  • Aldehydes
  • Phosphatidylethanolamines
  • Reactive Oxygen Species