Abstract
The sensing of viral infection by the innate immune system is dominated by the recognition of nucleic acids. New data now demonstrate that the fusion of viral and target-cell membranes leads to the activation of an immune response dependent on the adaptor STING.
MeSH terms
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Animals
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Cell Fusion*
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Herpesvirus 1, Human / immunology*
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Herpesvirus 1, Human / physiology*
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Humans
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Immunity, Innate*
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Interferon Type I / biosynthesis*
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Membrane Fusion*
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Membrane Proteins / metabolism*
Substances
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Interferon Type I
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Membrane Proteins
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STING1 protein, human
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Sting1 protein, mouse