Breaking the barrier: membrane fusion triggers innate antiviral immunity

Nat Immunol. 2012 Jul 19;13(8):713-5. doi: 10.1038/ni.2373.

Abstract

The sensing of viral infection by the innate immune system is dominated by the recognition of nucleic acids. New data now demonstrate that the fusion of viral and target-cell membranes leads to the activation of an immune response dependent on the adaptor STING.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Fusion*
  • Herpesvirus 1, Human / immunology*
  • Herpesvirus 1, Human / physiology*
  • Humans
  • Immunity, Innate*
  • Interferon Type I / biosynthesis*
  • Membrane Fusion*
  • Membrane Proteins / metabolism*

Substances

  • Interferon Type I
  • Membrane Proteins
  • STING1 protein, human
  • Sting1 protein, mouse