From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

Maxim G Uchuskin; Arkady S Pilipenko; Olga V Serdyuk; Igor V Trushkov; Alexander V Butin

doi:10.1039/c2ob25836f

From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

Org Biomol Chem. 2012 Sep 28;10(36):7262-5. doi: 10.1039/c2ob25836f.

Authors

Maxim G Uchuskin¹, Arkady S Pilipenko, Olga V Serdyuk, Igor V Trushkov, Alexander V Butin

Affiliation

¹ Research Institute of Heterocyclic Compounds Chemistry, Kuban State Technological University, Moskovskaya st. 2, Krasnodar, 350072, Russian Federation.

PMID: 22814312
DOI: 10.1039/c2ob25836f

Abstract

Indolo[3,2-c]quinolines are pharmacologically attractive class of heterocyclic compounds. The method of their synthesis, based on transformation of furfural, which is a large-scale product of treatment of biomass including agricultural and forestry wastes, has been developed. This method was utilized for the total synthesis of antimalarial alkaloid isocryptolepine and its derivatives.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antimalarials / chemical synthesis*
Antimalarials / chemistry
Biomass
Indole Alkaloids / chemical synthesis*
Indole Alkaloids / chemistry
Indoles / chemical synthesis*
Indoles / chemistry
Molecular Structure
Pharmaceutical Preparations / chemical synthesis
Pharmaceutical Preparations / chemistry*
Quinolines / chemical synthesis*
Quinolines / chemistry

Substances

Antimalarials
Indole Alkaloids
Indoles
Pharmaceutical Preparations
Quinolines
isocryptolepine