Abstract
Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Binding Sites
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Cell Line
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Cell Line, Tumor
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Fluorescent Dyes / analysis*
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Fluorescent Dyes / chemistry
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Humans
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Microscopy, Fluorescence
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Molecular Docking Simulation
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Proteasome Endopeptidase Complex / analysis*
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Proteasome Endopeptidase Complex / immunology
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Proteomics / methods
Substances
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Fluorescent Dyes
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LMP7 protein
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Proteasome Endopeptidase Complex