Liquid viruses by nanoscale engineering of capsid surfaces

Adv Mater. 2012 Aug 28;24(33):4557-63. doi: 10.1002/adma.201201032. Epub 2012 Jul 16.

Abstract

Surface engineering of plant virus capsids via cationization (1) and stoichiometric coupling of a polymer surfactant coronal layer (2) produces a highly concentrated, solvent-free liquid virus at 28 °C. These ionic bionanoconstructs are viscoelastic, retain plant infectivity and can be dispersed in a range of organic solvents for aerosol delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Capsid / chemistry*
  • Comovirus / chemistry*
  • Comovirus / physiology
  • Engineering / methods*
  • Fabaceae / virology
  • Models, Molecular
  • Nanotechnology / methods*
  • Optical Imaging
  • Protein Conformation
  • Surface Properties