Abstract
Phosphorylation is the predominant language of cell signaling. And, as with any common language, an abundance of dialects has evolved to convey complex information. We discuss here how biosensors are being used to decode this language, affording an unprecedented glimpse into spatio-temporal patterns of protein phosphorylation events within the cell.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biosensing Techniques
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Enzyme Activation / radiation effects
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Fluorescence Resonance Energy Transfer
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Genes, Reporter
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Humans
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Light
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Membrane Microdomains / metabolism
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Membrane Microdomains / radiation effects
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Phosphatidylinositol 3-Kinases / metabolism
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Protein Kinases / metabolism*
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Signal Transduction / radiation effects
Substances
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Protein Kinases
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Phosphatidylinositol 3-Kinases