Pathways of bone marrow mononuclear cell differentiation after transplantation into postinfarction heart

J P Baikova; T Kh Fatkhudinov; G B Bolshakova; T B Buharova; T K Dubovaya; L V Kaktursky; D V Goldshtein

doi:10.1007/s10517-011-1471-0

Pathways of bone marrow mononuclear cell differentiation after transplantation into postinfarction heart

Bull Exp Biol Med. 2011 Nov;152(1):128-32. doi: 10.1007/s10517-011-1471-0.

[Article in English, Russian]

Authors

J P Baikova¹, T Kh Fatkhudinov, G B Bolshakova, T B Buharova, T K Dubovaya, L V Kaktursky, D V Goldshtein

Affiliation

¹ Laboratory of Growth and Development, Research Institute of Human Morphology, Russian Academy of Medical Sciences, Russian State Medical University, Moscow, Russia.

PMID: 22803058
DOI: 10.1007/s10517-011-1471-0

Abstract

We studied homing and differentiation fate of transplanted bone marrow mononuclears after non-selective intracoronary injection on day 30 after acute myocardial infarction in rats. Mononuclear cells migrated to the cicatrix zone where they differentiated into fibroblasts and myofibroblasts. Mononuclear cells did not differentiate into cardiomyocytes, endothelial cells, or smooth muscle cells of vascular media. Stimulation of angiogenesis and reparation of the myocardium was observed under these conditions.

MeSH terms

Animals
Bone Marrow Cells / physiology*
Bone Marrow Transplantation*
Cell Differentiation*
Cell Tracking
Cicatrix / pathology
Coronary Vessels / physiopathology
Fibroblasts / pathology
Heart / physiology
Male
Myocardial Infarction / pathology
Myocardial Infarction / therapy*
Myofibroblasts / pathology
Neovascularization, Physiologic
Rats
Rats, Sprague-Dawley
Regeneration