Aortic homograft endocarditis caused by Cardiobacterium hominis and complicated by agranulocytosis due to ceftriaxone

BMJ Case Rep. 2010 Nov 26:2010:bcr0420102894. doi: 10.1136/bcr.04.2010.2894.

Abstract

The present report describes a very rare case of an aortic homograft valve endocarditis caused by Cardiobacterium hominis. The case was complicated by an agranulocytosis after 3 weeks of antibiotic treatment induced by ceftriaxone. Alternative oral treatment with ciprofloxacin and rifampicin was successful, no surgical intervention was needed and homograft function could be preserved.

Publication types

  • Case Reports

MeSH terms

  • Agranulocytosis / chemically induced*
  • Agranulocytosis / complications
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Aortic Valve / abnormalities*
  • Aortic Valve / transplantation*
  • Aortic Valve Insufficiency / diagnosis
  • Aortic Valve Insufficiency / surgery*
  • Bacteremia / diagnosis
  • Bacteremia / drug therapy
  • Bioprosthesis
  • Cardiobacterium*
  • Ceftriaxone / adverse effects*
  • Ceftriaxone / therapeutic use
  • Drug Therapy, Combination
  • Endocarditis, Bacterial / diagnosis*
  • Endocarditis, Bacterial / drug therapy
  • Follow-Up Studies
  • Gram-Negative Bacterial Infections / diagnosis*
  • Gram-Negative Bacterial Infections / drug therapy
  • Heart Valve Prosthesis
  • Humans
  • Infant, Newborn
  • Male
  • Middle Aged
  • Prosthesis Failure
  • Recurrence
  • Reoperation
  • Transplantation, Homologous

Substances

  • Anti-Bacterial Agents
  • Ceftriaxone