Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs

Chem Commun (Camb). 2012 Sep 4;48(68):8559-61. doi: 10.1039/c2cc33786j. Epub 2012 Jul 16.

Abstract

A modified paullone ligand bearing a TEMPO free-radical unit (HL) and its ruthenium(II) and osmium(II)-arene complexes [M(p-cymene)(HL)Cl]Cl·nH(2)O (M = Ru, Os) exhibit high antiproliferative activity in human cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / toxicity
  • Benzazepines / chemistry*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Coordination Complexes / chemistry*
  • Coordination Complexes / toxicity
  • Crystallography, X-Ray
  • Cyclic N-Oxides / chemistry*
  • Drug Screening Assays, Antitumor
  • Free Radicals / chemistry
  • Humans
  • Molecular Conformation
  • Osmium / chemistry*
  • Ruthenium / chemistry*

Substances

  • Antineoplastic Agents
  • Benzazepines
  • Coordination Complexes
  • Cyclic N-Oxides
  • Free Radicals
  • paullone
  • Osmium
  • Ruthenium
  • TEMPO