Abstract
A modified paullone ligand bearing a TEMPO free-radical unit (HL) and its ruthenium(II) and osmium(II)-arene complexes [M(p-cymene)(HL)Cl]Cl·nH(2)O (M = Ru, Os) exhibit high antiproliferative activity in human cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / toxicity
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Benzazepines / chemistry*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Coordination Complexes / chemistry*
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Coordination Complexes / toxicity
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Crystallography, X-Ray
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Cyclic N-Oxides / chemistry*
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Drug Screening Assays, Antitumor
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Free Radicals / chemistry
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Humans
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Molecular Conformation
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Osmium / chemistry*
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Ruthenium / chemistry*
Substances
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Antineoplastic Agents
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Benzazepines
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Coordination Complexes
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Cyclic N-Oxides
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Free Radicals
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paullone
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Osmium
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Ruthenium
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TEMPO