Cytochrome c heme lyase can mature a fusion peptide composed of the amino-terminal residues of horse cytochrome c

Chem Commun (Camb). 2012 Aug 28;48(67):8344-6. doi: 10.1039/c2cc31112g. Epub 2012 Jul 13.

Abstract

It is shown that cytochrome c heme lyase (CCHL) attaches heme covalently to peptides composed of the N-terminal segment of cyt c fused to a non-heme containing protein, lending insight into the substrate specificity of CCHL and providing a new route to artificial heme proteins.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cytochrome c Group / chemistry*
  • Cytochrome c Group / metabolism
  • Heme / chemistry*
  • Heme / metabolism
  • Horses
  • Lyases / chemistry*
  • Models, Molecular
  • Molecular Sequence Data
  • Peptides / chemistry*
  • Peptides / metabolism
  • Protein Processing, Post-Translational*
  • Substrate Specificity

Substances

  • Cytochrome c Group
  • Peptides
  • Heme
  • Lyases
  • cytochrome C synthetase