Abstract
Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects
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Aquatic Organisms / chemistry
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Caspase 3 / metabolism
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DNA Fragmentation / drug effects
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Humans
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Japan
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Magnetic Resonance Spectroscopy
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Pigments, Biological / chemistry
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Pigments, Biological / isolation & purification*
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Pigments, Biological / pharmacology
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Prodigiosin / analogs & derivatives
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Prodigiosin / isolation & purification*
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Prodigiosin / pharmacology
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Pseudoalteromonas / chemistry*
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Spectrometry, Mass, Electrospray Ionization
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U937 Cells
Substances
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Antineoplastic Agents
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Pigments, Biological
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Caspase 3
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Prodigiosin