A growing number of childhood diseases, such as allergic disorders (e.g., allergic rhinitis, atopic dermatitis and asthma) and other immune-mediated diseases (e.g., Type 1 diabetes), have been linked to environmental exposures during prenatal and early postnatal life, along with genetic determinants. Immunological mechanisms, diagnosis, treatment, prevention and management of allergies and other immune-mediated diseases were discussed at the 2012 Annual Meeting of the American Academy of Allergy, Asthma & Immunology in Orlando, FL, USA, 2-6 March 2012.