Rapid fabrication of complex 3D extracellular microenvironments by dynamic optical projection stereolithography

Adv Mater. 2012 Aug 16;24(31):4266-70. doi: 10.1002/adma.201202024. Epub 2012 Jul 12.

Abstract

The topographic features of the extracelluar matrix (ECM) lay the foundation for cellular behavior. A novel biofabrication method using a digital-mirror device (DMD), called dynamic optical projection stereolithography (DOPsL) is demonstrated. This robust and versatile platform can generate complex biomimetic scaffolds within seconds. Such 3D scaffolds have promising potentials for studying cell interactions with microenvironments in vitro and in vivo.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Extracellular Matrix / chemistry*
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Mice
  • NIH 3T3 Cells
  • Nanotechnology
  • Surface Properties
  • Tissue Engineering
  • Ultraviolet Rays

Substances

  • Biocompatible Materials