Radiolabeled γ-AApeptides: a new class of tracers for positron emission tomography

Chem Commun (Camb). 2012 Aug 14;48(63):7850-2. doi: 10.1039/c2cc33620k. Epub 2012 Jul 2.

Abstract

A γ-AApeptide-based tracer for positron emission tomography imaging of integrin α(v)β(3) is reported. Despite its shorter sequence and linear nature, this tracer had comparable integrin α(v)β(3) binding affinity to the cyclic arginine-glycine-aspartic acid peptide but significantly higher resistance to enzymatic degradation and better stability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Copper Radioisotopes / chemistry
  • Humans
  • Integrin alphaVbeta3 / metabolism*
  • Isotope Labeling
  • Mice
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / metabolism*
  • Positron-Emission Tomography
  • Pronase / metabolism
  • Protein Binding
  • Radiopharmaceuticals / chemistry
  • Radiopharmaceuticals / metabolism*
  • Tissue Distribution
  • Transplantation, Heterologous

Substances

  • Copper Radioisotopes
  • Integrin alphaVbeta3
  • Peptides, Cyclic
  • Radiopharmaceuticals
  • cyclic arginine-glycine-aspartic acid peptide
  • Pronase