Isolation and neuroprotective activities of acylated iridoids from Valeriana jatamansi

Chem Biodivers. 2012 Jul;9(7):1382-8. doi: 10.1002/cbdv.201100238.

Abstract

Three new iridoids, jatairidoids A-C (1-3, resp.), have been isolated from the roots of Valeriana jatamansi (V. wallichii). Their structures were elucidated by spectroscopic methods (IR, ESI-MS, HR-ESI-MS, 1D- and 2D-NMR). Compounds 1 and 2 are C(3)-epimers. The three compounds were evaluated for their neuroprotective effects against MPP(+)-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells. All the isolates exhibited moderate neuroprotective effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acylation
  • Dopaminergic Neurons / drug effects*
  • Humans
  • Iridoids* / chemistry
  • Iridoids* / pharmacology
  • Models, Molecular
  • Neuroblastoma
  • Neuroprotective Agents* / chemistry
  • Neuroprotective Agents* / pharmacology
  • Plant Extracts / chemistry*
  • Plant Roots / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Valerian / chemistry*

Substances

  • Iridoids
  • Neuroprotective Agents
  • Plant Extracts