Abstract
Sapovirus (SaV) is an important pathogen that causes acute gastroenteritis in humans. Human SaV is highly diverse genetically and is classified into multiple genogroups and genotypes. At present, there is no clear evidence for gastroenteritis cases caused by re-infection with SaV. We found that two individuals were sequentially infected with SaVs of two different genogroups and had gastroenteritis after each infection, although in one of the subsequent cases, both SaV and norovirus were detected. We also found a genetic shift in SaVs from gastroenteritis outpatients in the same geographical location. Our results suggest that protective immunity may be at least genogroup-specific for SaV.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Caliciviridae Infections / immunology
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Caliciviridae Infections / virology*
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Child
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Child, Preschool
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Evolution, Molecular*
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Feces / virology
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Female
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Gastroenteritis / immunology
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Gastroenteritis / virology*
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Genotype
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Humans
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Infant
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Male
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Molecular Sequence Data
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Polymerase Chain Reaction / methods
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Sapovirus / classification*
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Sapovirus / genetics*
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Sapovirus / isolation & purification
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Sequence Analysis, DNA
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Species Specificity
Associated data
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GENBANK/AB689798
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GENBANK/AB689799
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GENBANK/AB689800
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GENBANK/AB689801
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