Silica-based nanoparticles for biomedical applications

Drug Discov Today. 2012 Oct;17(19-20):1147-54. doi: 10.1016/j.drudis.2012.06.014. Epub 2012 Jul 6.

Abstract

In this short review we highlight novel uses of silica-based nanoparticles (NPs) in the biomedical sector. Silica NPs are widely used in nanotechnology because they are easy to prepare and inexpensive to produce. Their specific surface characteristics, porosity and capacity for functionalization make them good tools for biomolecule detection and separation, providing solid media for drug delivery systems and acting as contrast agent protectors. In addition, they are used as safety and biocompatible pharmaceutical additives. Here, we focus on novel techniques based on silica NPs for the most important biomedical applications.

Publication types

  • Review

MeSH terms

  • Adsorption
  • DNA / chemistry
  • Drug Carriers / chemistry
  • Excipients / chemistry
  • Gene Transfer Techniques
  • Nanoparticles / chemistry*
  • Proteins / chemistry
  • Silicon Dioxide / chemistry*

Substances

  • Drug Carriers
  • Excipients
  • Proteins
  • Silicon Dioxide
  • DNA