Distinct requirement of RNA polymerase II CTD phosphorylations in budding and fission yeast

Clément Cassart; Julie Drogat; Valérie Migeot; Damien Hermand

doi:10.4161/trns.21066

Distinct requirement of RNA polymerase II CTD phosphorylations in budding and fission yeast

Transcription. 2012 Sep-Oct;3(5):231-4. doi: 10.4161/trns.21066. Epub 2012 Sep 1.

Authors

Clément Cassart¹, Julie Drogat, Valérie Migeot, Damien Hermand

Affiliation

¹ Namur Research College (NARC), The University of Namur, Namur, Belgium.

Abstract

The "CTD code" links the combinatorial potential of the modifications found on the Rpb1 C-terminal domain (CTD) to the growing group of CTD binding effectors. The genetic dissection of serine 2 and serine 7 function within the CTD in both budding and fission yeast reveals distinct in vivo requirement.

Keywords: CTD; RNA polymerase II; cell differentiation; phosphorylation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Mutation
Phenotype
Phosphorylation
Protein Structure, Tertiary / physiology*
RNA Polymerase II / chemistry
RNA Polymerase II / physiology*
Saccharomycetales / physiology*
Schizosaccharomyces / physiology*

Substances

RNA Polymerase II