p53 and metabolism: old player in a new game

Nirmalya Sen; Yatendra Kumar Satija; Sanjeev Das

doi:10.4161/trns.20094

p53 and metabolism: old player in a new game

Transcription. 2012 May-Jun;3(3):119-23. doi: 10.4161/trns.20094.

Authors

Nirmalya Sen¹, Yatendra Kumar Satija, Sanjeev Das

Affiliation

¹ Molecular Oncology Laboratory, National Institute of Immunology Aruna Asaf Ali Marg, New Delhi, India.

Abstract

Metabolic reprogramming is an integral part of tumorigenesis. Tumor suppressor p53 is a well studied transcription factor intimately linked with the control of cell cycle progression and apoptosis. Here, we discuss the emerging role of p53 in the transcriptional regulation of metabolism. This activity is a key component of p53 tumor suppression function.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Apoptosis
Cell Cycle
Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / metabolism*
Gene Expression Regulation, Neoplastic*
Humans
Transcription Factors
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism*

Substances

Transcription Factors
Tumor Suppressor Protein p53