The challenge of acute rejection in intestinal transplantation

Pediatr Surg Int. 2012 Aug;28(8):855-9. doi: 10.1007/s00383-012-3110-x. Epub 2012 Jul 4.

Abstract

Early diagnosis and treatment of acute cellular rejection (ACR) after intestinal transplantation (ITx) is challenging. We report the outcome of three patients: two presented mild ACR improved with steroids. One presented steroid-resistant severe rejection, improved after rabbit anti-thymocyte globulin (r-ATG), but unfortunately died for encephalitis caused by opportunistic infections.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anastomosis, Surgical
  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Antilymphocyte Serum / administration & dosage*
  • Basiliximab
  • Child
  • Daclizumab
  • Encephalitis / etiology
  • Fatal Outcome
  • Female
  • Graft Rejection / diagnosis*
  • Graft Rejection / drug therapy*
  • Humans
  • Immunoglobulin G / therapeutic use
  • Immunosuppressive Agents / administration & dosage*
  • Intestinal Diseases / surgery
  • Intestinal Volvulus / surgery
  • Intestines / transplantation*
  • Male
  • Nervous System Diseases / surgery
  • Recombinant Fusion Proteins / therapeutic use
  • Short Bowel Syndrome / surgery
  • Tacrolimus / administration & dosage

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antilymphocyte Serum
  • Immunoglobulin G
  • Immunosuppressive Agents
  • Recombinant Fusion Proteins
  • Basiliximab
  • Daclizumab
  • Tacrolimus

Supplementary concepts

  • Neuronal intestinal pseudoobstruction