Plasmodium falciparum infection in pregnant women attending antenatal care in Luanda, Angola

Rev Soc Bras Med Trop. 2012 Jun;45(3):369-74. doi: 10.1590/s0037-86822012000300017.

Abstract

Introduction: Malaria during pregnancy remains a serious public health problem. The aim of this study was to establish the prevalence and possible risk factors for malaria in pregnant women attending antenatal care at Augusto Ngangula Specialized General Hospital in Luanda, Angola.

Methods: Pregnant women (679 total) who attended antenatal care from April to September 2008 were included in the study after signing informed consent. For each participant, the social-demographic profile and malaria and obstetric histories were investigated via a questionnaire. Diagnosis was made by optic microscopy, and hemoglobin concentration measured. The associations between age, parity, gestational age, residence, schooling, malaria during gravity, anemia and treatment with incidence of Plasmodium falciparum infection were analyzed through logistic regression.

Results: During the period of study, 74 (10.9%) out of 679 women were infected by P. falciparum. The average concentration of hemoglobin was 11.1 ± 0.07 g/dL, and there were significant associations between the history of malaria during pregnancy, P. falciparum infection (p<0.01) and anemia at the time of observation (p<0.001).

Conclusions: Previous history of malaria during pregnancy represents a risk factor for current infection and anemia was an important complication associated with malaria, even in women who were treated with sulfadoxine-pyrimethamine during pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Angola / epidemiology
  • Antimalarials / therapeutic use
  • Child
  • Drug Combinations
  • Female
  • Humans
  • Malaria, Falciparum / diagnosis
  • Malaria, Falciparum / drug therapy
  • Malaria, Falciparum / epidemiology*
  • Middle Aged
  • Pregnancy
  • Pregnancy Complications, Parasitic / diagnosis
  • Pregnancy Complications, Parasitic / drug therapy
  • Pregnancy Complications, Parasitic / epidemiology*
  • Prenatal Diagnosis / statistics & numerical data*
  • Prevalence
  • Pyrimethamine / therapeutic use
  • Risk Factors
  • Socioeconomic Factors
  • Sulfadoxine / therapeutic use
  • Young Adult

Substances

  • Antimalarials
  • Drug Combinations
  • fanasil, pyrimethamine drug combination
  • Sulfadoxine
  • Pyrimethamine