Post-transcriptional control of type I interferon induction by porcine reproductive and respiratory syndrome virus in its natural host cells

Viruses. 2012 May;4(5):725-33. doi: 10.3390/v4050725. Epub 2012 May 2.

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is not only a poor inducer of type I interferon but also inhibits the efficient induction of type I interferon by porcine transmissible gastroenteritis virus (TGEV) and synthetic dsRNA molecules, Poly I:C. However, the mechanistic basis by which PRRSV interferes with the induction of type I interferon in its natural host cells remains less well defined. The purposes of this review are to summarize the key findings in supporting the post-transcriptional control of type I interferon in its natural host cells and to propose the possible role of translational control in the regulation of type I interferon induction by PRRSV.

Keywords: PRRSV; Type I interferon; post-transcriptional regulation; translational control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Immune Evasion
  • Interferon Type I / biosynthesis*
  • Interferon Type I / immunology
  • Poly I-C / immunology
  • Porcine respiratory and reproductive syndrome virus / immunology
  • Porcine respiratory and reproductive syndrome virus / pathogenicity*
  • Protein Biosynthesis*
  • Swine
  • Transmissible gastroenteritis virus / immunology

Substances

  • Interferon Type I
  • Poly I-C