Inbreeding as a cause for deafness: Dadhkai study

Indian J Hum Genet. 2012 Jan;18(1):71-4. doi: 10.4103/0971-6866.96655.

Abstract

Background: We report on the higher prevalence of deaf-mutes from a village in Jammu and Kashmir State of India.

Materials and methods: A cross-sectional study among 79 deaf mutes using pedigree analysis, audiometry, imaging and molecular analysis.

Results: A high rate of hereditary deafness with 79 individuals diagnosed to be suffering from non-syndrome deafness in a total population of 2452 individuals residing in the village.

Interpretation: Flourishing of intermarriages led to a population with high prevalence of deafness.

Keywords: Dadhkai; deafness; inbreeding.