¹H, ¹³C and ¹⁵N assignment of D2 domain of human fibroblast growth factor receptor 4

Bettina Elshorst; Krishna Saxena; Ulrich Schieborr; Harald Schwalbe

doi:10.1007/s12104-012-9405-y

¹H, ¹³C and ¹⁵N assignment of D2 domain of human fibroblast growth factor receptor 4

Biomol NMR Assign. 2013 Oct;7(2):179-82. doi: 10.1007/s12104-012-9405-y. Epub 2012 Jul 1.

Authors

Bettina Elshorst¹, Krishna Saxena, Ulrich Schieborr, Harald Schwalbe

Affiliation

¹ Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt, Germany.

PMID: 22752790
DOI: 10.1007/s12104-012-9405-y

Abstract

Fibroblast growth factor receptor (FGFR) 4 has been associated with progression of melanoma, breast, head and neck and hepatocellular carcinoma and is therefore an interesting target for therapeutic intervention (Ho et al. in J Hepatol 50:118-127, 2009). The extracellular D2 domain of the FGFR4 receptor contains a heparin binding site and the main interaction site with the fibroblast growth factor. We report the sequential backbone and side chain resonance assignment of the D2 domain of human FGFR4.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Carbon Isotopes
Humans
Molecular Sequence Data
Nitrogen Isotopes
Nuclear Magnetic Resonance, Biomolecular*
Protein Structure, Tertiary
Protons*
Receptor, Fibroblast Growth Factor, Type 4 / chemistry*

Substances

Carbon Isotopes
Nitrogen Isotopes
Protons
FGFR4 protein, human
Receptor, Fibroblast Growth Factor, Type 4