A twofold helix (2(1) helix) is an essential motif in approximately 70% of organic crystals. Although handedness of 2(1) helix has not been discussed from a mathematical viewpoint, we noticed that the handedness can be defined by considering the molecular shape and manner of assembly. Herein we propose the supramolecular-tilt-chirality (STC) method to define the handedness, and illustrate it by way of some examples. We believe that establishment of the systematic rules for supramolecular chirality will contribute to the progression of supramolecular chemistry and material science.
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