Currently several endovascular modalities and devices are available for use in acute ischemic stroke setting. Limited data exist regarding the relative efficacy of these different options when used individually or in combination. The primary objective of this study was to retrospectively compare the recanalization rates of various endovascular options when used for the treatment of acute ischemic stroke in the anterior cerebral circulation. We retrospectively reviewed 132 consecutive patients treated endovascularly at our center for acute ischemic stroke in the anterior cerebral circulation. Recanalization was defined as mTIMI of ≥ 2 while complete recanalization was defined as mTIMI of 4. Statistical analysis was performed to determine the modality or combination of modalities associated with best recanalization rate. Recanalization was achieved in 74% of patients while complete recanalization was achieved in 39% of patients. No individual endovascular therapy was significantly different from others in achieving recanalization. Where a multimodality approach was used, combination of angioplasty with intra- or extracranial stent placement was significantly (p=0.05) associated with recanalization. On regression analysis, combination of intra-arterial tPA with a mechanical modality (p=0.09) was significantly associated with recanalization while combination of intravenous tPA with intracranial stent placement (p=0.06) was significantly associated with complete recanalization. Combination of pharmacological and mechanical modalities in the setting of multimodal therapy is associated with increased likelihood of successful recanalization in patients with acute ischemic stroke in the anterior cerebral circulation. Stent placement in acute stroke setting is promising and needs further exploration. Further prospective studies are needed.