One-pot multicomponent cascade reaction of N,S-ketene acetal: solvent-free synthesis of imidazo[1,2-a]thiochromeno[3,2-e]pyridines

Org Lett. 2012 Jul 6;14(13):3470-3. doi: 10.1021/ol301441v. Epub 2012 Jun 26.

Abstract

Unprecedented imidazo[1,2-a]thiochromeno[3,2-e]pyridines have been synthesized via a three-component cascade reaction under solvent-free conditions. This one-pot transformation involving multiple steps and not requiring the use of transition metal catalysts constructs three new C-C bonds, two C-N bonds, one C-S bond, and three new rings with all reactants efficiently utilized.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetals / chemistry*
  • Chromans / chemical synthesis*
  • Chromans / chemistry
  • Crystallography, X-Ray
  • Ethylenes / chemistry*
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Ketones / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry

Substances

  • Acetals
  • Chromans
  • Ethylenes
  • Imidazoles
  • Ketones
  • Pyridines
  • imidazo(1,2-a)thiochromeno(3,2-e)pyridine
  • ketene