A sulfur tripod glycoconjugate that releases a high-affinity copper chelator in hepatocytes

Angew Chem Int Ed Engl. 2012 Jul 23;51(30):7445-8. doi: 10.1002/anie.201203255. Epub 2012 Jun 14.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asialoglycoprotein Receptor / metabolism
  • Cell Line
  • Chelating Agents / administration & dosage*
  • Chelating Agents / chemistry
  • Chelating Agents / pharmacology
  • Copper / metabolism*
  • Disulfides / chemistry
  • Drug Delivery Systems*
  • Glycoconjugates / chemistry*
  • Glycoconjugates / metabolism
  • Hepatocytes / drug effects
  • Hepatocytes / metabolism*
  • Humans
  • Nitrilotriacetic Acid / administration & dosage*
  • Nitrilotriacetic Acid / chemistry
  • Nitrilotriacetic Acid / pharmacology
  • Oxidation-Reduction
  • Prodrugs / administration & dosage*
  • Prodrugs / chemistry
  • Prodrugs / pharmacology

Substances

  • Asialoglycoprotein Receptor
  • Chelating Agents
  • Disulfides
  • Glycoconjugates
  • Prodrugs
  • Copper
  • Nitrilotriacetic Acid