Aptamer-based polymerase chain reaction for ultrasensitive cell detection

Chem Commun (Camb). 2012 Aug 4;48(60):7465-7. doi: 10.1039/c2cc32085a. Epub 2012 Jun 25.

Abstract

A new system was developed for sensitive and selective detection of tumor cells taking advantage of cell-attached aptamers amplified by PCR and output signals amplified by cationic conjugated polymers.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aptamers, Nucleotide / analysis*
  • Aptamers, Nucleotide / metabolism
  • Cell Line, Tumor
  • Humans
  • Leukemia, Myeloid, Acute / diagnosis*
  • Leukemia, Myeloid, Acute / metabolism
  • Polymerase Chain Reaction* / methods
  • Sensitivity and Specificity

Substances

  • Aptamers, Nucleotide