Genetic variation in B cell-activating factor of the TNF family (BAFF) and asthma exacerbations among African American subjects

J Allergy Clin Immunol. 2012 Oct;130(4):996-9.e6. doi: 10.1016/j.jaci.2012.04.047. Epub 2012 Jun 22.

Abstract

A BAFF polymorphism is associated with asthma exacerbations and serum BAFF levels. BAFF expression in vivo increases in natural rhinovirus infection. BAFF may play a role in airway antiviral immunity and impact asthma exacerbation rates.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asthma / genetics*
  • B-Cell Activating Factor / genetics*
  • Black or African American / genetics*
  • Genetic Variation
  • Humans
  • Polymorphism, Single Nucleotide*
  • Proportional Hazards Models
  • RNA, Messenger / analysis

Substances

  • B-Cell Activating Factor
  • RNA, Messenger
  • TNFSF13B protein, human