Abstract
Osteomyelitis is an infectious disease located in the bone or bone marrow. Long-circulating and pH-sensitive liposomes containing a technetium-99m-labeled antibiotic, ceftizoxime, (SpHL-(99m)Tc-CF) were developed to identify osteomyelitis foci. Biodistribution studies and scintigraphic images of bone infection or non infection-bearing rats that had been treated with these liposomes were performed. A high accumulation in infectious foci and high values in the target-non target ratio could be observed. These results indicate the potential of SpHL-(99m)Tc-CF as a potential agent for the diagnosis of bone infections.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Ceftizoxime / administration & dosage
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Ceftizoxime / analogs & derivatives*
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Ceftizoxime / chemistry
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Ceftizoxime / pharmacokinetics
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Ceftizoxime / therapeutic use
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Disease Models, Animal
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Hydrogen-Ion Concentration
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Liposomes
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Male
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Molecular Structure
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Organ Specificity
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Organotechnetium Compounds / administration & dosage
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Organotechnetium Compounds / chemistry
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Organotechnetium Compounds / pharmacokinetics*
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Organotechnetium Compounds / therapeutic use*
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Osteomyelitis / drug therapy*
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Rats
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Rats, Wistar
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Staphylococcus aureus / drug effects
Substances
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Liposomes
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Organotechnetium Compounds
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technetium 99m ceftizoxime
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Ceftizoxime