Abstract
Type 2C protein phosphatases (PP2Cs) form a structurally unique class of Mg(2+)-/Mn(2+)-dependent enzymes. PP2Cs are evolutionary conserved from prokaryotes to higher eukaryotes and play a prominent role in stress signalling. In this review, we focus on the evolution, function and regulation of the plant PP2Cs. Members of a subclass of plant PP2Cs counteract mitogen-activated protein kinase pathways, whereas members of other subfamilies function as co-receptors for the phytohormone abscisic acid. Recent structural analyses of abscisic acid receptors have elucidated the mode of ligand-dependent regulation and substrate targeting.
© 2012 The Authors Journal compilation © 2012 FEBS.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Abscisic Acid / metabolism
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Abscisic Acid / pharmacology
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Evolution, Molecular
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Gene Expression Regulation, Plant / drug effects
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Models, Molecular
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Phosphoprotein Phosphatases / classification
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Phosphoprotein Phosphatases / genetics
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Phosphoprotein Phosphatases / metabolism*
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Phylogeny
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Plant Growth Regulators / metabolism
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Plant Growth Regulators / pharmacology
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Plant Proteins / chemistry
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Plant Proteins / genetics
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Plant Proteins / metabolism*
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Plants / enzymology*
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Plants / genetics
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Plants / metabolism
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Protein Phosphatase 2C
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Protein Structure, Tertiary
Substances
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Plant Growth Regulators
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Plant Proteins
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Abscisic Acid
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Phosphoprotein Phosphatases
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Protein Phosphatase 2C