Abstract
This review is devoted to antimicrobial peptides (AMP's) that demonstrate activity against bacteria, viruses and fungi. It considers structure and mechanism of AMP interaction with lipid membrane and intracellular targets of pathogens. Special attention is paid to modem state and perspectives of AMP practical application and also to approaches that increase efficacy and reduce toxicity of AMP by chemical modification of their structure.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Antimicrobial Cationic Peptides / pharmacology
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Cell Membrane / drug effects
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Humans
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Membrane Lipids / chemistry
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Membrane Lipids / metabolism
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Peptides / chemistry*
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Peptides / pharmacology
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Antimicrobial Cationic Peptides
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Antiviral Agents
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Membrane Lipids
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Peptides
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omiganan pentahydrochloride