In the title compound, C(15)H(19)N(3)O(6), the amide planes are inclined at dihedral angles of 0.8 (6) and 12.1 (3)° with respect to the central pyridine ring. The mean planes of the corresponding methyl acetate groups form dihedral angles of 41.76 (13) and 86.48 (15)°, respectively with the mean plane of pyridine ring. A pair of weak intra-molecular N-H⋯N hydrogen bonds generate an S(5)S(5) ring motif in the mol-ecule. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds into [001] chains. The chains are cross-linked by C-H⋯O hydrogen bonds into layers lying parallel to bc plane. The crystal packing also features a C-H⋯π inter-action.