Computational modeling of the human atrial anatomy and electrophysiology

Med Biol Eng Comput. 2012 Aug;50(8):773-99. doi: 10.1007/s11517-012-0924-6. Epub 2012 Jun 21.

Abstract

This review article gives a comprehensive survey of the progress made in computational modeling of the human atria during the last 10 years. Modeling the anatomy has emerged from simple "peanut"-like structures to very detailed models including atrial wall and fiber direction. Electrophysiological models started with just two cellular models in 1998. Today, five models exist considering e.g. details of intracellular compartments and atrial heterogeneity. On the pathological side, modeling atrial remodeling and fibrotic tissue are the other important aspects. The bridge to data that are measured in the catheter laboratory and on the body surface (ECG) is under construction. Every measurement can be used either for model personalization or for validation. Potential clinical applications are briefly outlined and future research perspectives are suggested.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Atrial Function / physiology*
  • Computer Simulation
  • Electrocardiography / methods*
  • Heart Conduction System / physiology*
  • Humans
  • Models, Cardiovascular*
  • Myocytes, Cardiac / physiology*