Placental expression of indoleamine 2,3-dioxygenase

Peter Sedlmayr; Astrid Blaschitz

doi:10.1007/s10354-012-0082-3

Placental expression of indoleamine 2,3-dioxygenase

Wien Med Wochenschr. 2012 May;162(9-10):214-9. doi: 10.1007/s10354-012-0082-3.

Authors

Peter Sedlmayr¹, Astrid Blaschitz

Affiliation

¹ Center for Molecular Medicine, Institute for Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria. peter.sedlmayr@medunigraz.at

PMID: 22717876
DOI: 10.1007/s10354-012-0082-3

Abstract

This review focuses on the placental expression of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase-1 (IDO1) and its potential roles, which may not only encompass immunosuppression and antimicrobial activity, but also vasodilation based on the endothelial expression on both sides of the feto-maternal interface.

Publication types

Review

MeSH terms

Bacterial Infections / immunology
Endothelium, Vascular / physiopathology
Female
Fetal Growth Retardation / physiopathology
Gestational Age
Human Umbilical Vein Endothelial Cells
Humans
Immune Tolerance / physiology
Indoleamine-Pyrrole 2,3,-Dioxygenase / physiology*
Infant, Newborn
Maternal-Fetal Exchange / physiology
Placenta / blood supply
Placenta / physiopathology*
Pre-Eclampsia / physiopathology
Pregnancy

Substances

Indoleamine-Pyrrole 2,3,-Dioxygenase