Abstract
We prepared a series of new iminosugar-ferrocene hybrids displaying potent inhibition of fucosidase (bovine kidney) and inactivation of MDA-MB-231 breast cancer cells proliferation at low micromolar concentrations. The synthetic route brought to light an unprecedented isomerisation of a 2-ethanalylpyrrolidine.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antineoplastic Agents / chemistry*
-
Antineoplastic Agents / pharmacology
-
Cattle
-
Cell Line, Tumor
-
Cell Proliferation
-
Drug Screening Assays, Antitumor
-
Ferrous Compounds / chemistry*
-
Ferrous Compounds / pharmacology
-
Imino Sugars / chemistry*
-
Imino Sugars / pharmacology
-
Isomerism
-
Metallocenes
-
Pyrrolidines / chemistry
-
alpha-L-Fucosidase / antagonists & inhibitors
Substances
-
Antineoplastic Agents
-
Ferrous Compounds
-
Imino Sugars
-
Metallocenes
-
Pyrrolidines
-
alpha-L-Fucosidase
-
ferrocene