Itch pathophysiology may differ among ethnic groups

Int J Dermatol. 2012 Jul;51(7):771-6. doi: 10.1111/j.1365-4632.2011.05274.x.

Abstract

The prevalence of itch is higher in individuals with darker skin types. In this paper, we review the systems involved in the physiology of itch and how they may differ across the races. Current data point out that the differences may be explained by barrier function, mast cell physiology, and itch receptor polymorphisms.

Publication types

  • Review

MeSH terms

  • Humans
  • Mast Cells / physiology
  • Neurons / physiology*
  • Pruritus / ethnology*
  • Pruritus / genetics
  • Pruritus / physiopathology*
  • Pruritus / psychology
  • Racial Groups*
  • Receptors, Histamine / physiology
  • Stress, Psychological / physiopathology
  • TRPV Cation Channels / physiology
  • Water Loss, Insensible / physiology

Substances

  • Receptors, Histamine
  • TRPV Cation Channels