Abstract
A mild and versatile method for the synthesis of some novel indole-1-carbinols has been developed via one-pot reaction of indoles and paraformaldehyde in the presence of an excess of CaO, MgO, ZnO or TiO(2). The solvent-free reaction provided all the indole derivatives in moderate to good yields and short reaction times. Moreover, the effect of some selected indole-1-carbinols on cell proliferation of the hepatoma cell line FaO was evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Carcinoma, Hepatocellular / drug therapy
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Cell Proliferation / drug effects
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Indoles / chemical synthesis*
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Indoles / pharmacology
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Liver Neoplasms / drug therapy
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Methanol / chemical synthesis*
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Methanol / pharmacology
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Rats
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Indoles
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Methanol